Clinical trials are the foundation on which medical innovation is built beginning from the development of a new treatment or therapy. The grim reality, however, is that conventional models for conducting clinical trials are frequently faced with recruitment challenges for participants from the remote and rural areas. Complete Decentralized Clinical Trials (DCT) methodologies or decentralized clinical trials one conceivable solution to avert this scourge by employing technology to facilitate patient recruitment and inclusion. With such disparities in access to health care throughout India, DCTs can be regarded as an effective revolution in clinical research.