Recombinant Rabbit Monoclonal Anti Npas4 Antibodywe Have Developed An Anti Npas4 Recombinant Rabbit Monoclonal Antibody With High Specificity Demonstrated In Npas4 Ko Micethis Npas4 Antibody Can Be Used To Mark Active Neurons In Brain Slices And In Primary Culturesthe Ab Has Worked Well In All Methods Testedincluding Western Blottingimmunohistochemistryimmunocytochemistrychip Seq And Idisco Whole Brain Staining Npas4 As A Marker Of Recent Neuronal Activityneuronal Activity Engages Biochemical Signaling Pathways That Produce Alterations In Gene Expression Leading To Long Term Adaptive Changes In Neurons That Are Fundamental To Behavioral Plasticitythusimmediate Early Geneieginduction Is Commonly Used To Visualize Recent Neuronal Activityhoweverthe Iegs Traditionally Used To Mark Neuronal Activitye G Arccfos And Egr1 Zif268Are Also Turned On By Extrinsic Factors Such As Neurotrophins And Neuromodulators That Raise Campin Contrastthe Neuron Specific Ieg Npas4Is Strongly Induced By Neuronal Activitybut Does Not Respond To These Other Factors Lin Et Al 2008 Furthernpas4 Expression Is More Rapid And Transient Than Other Iegsramamoorthi Et Al 2011 This Tight Tuning To Neuronal Activity Makes Npas4 An Ideal Marker Of Neuronal Activity In The Brain
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| Company Name | Activity Signaling Llc |
| Country |
United States
|
| Address | N/A |
| Telephone | N/A |
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