Avidity Llc Was Founded In 1996 And Is Located In Colorful Coloradoavidity S Patented Avitag Sequence Enables Researchers Around The World To Connect Molecules Via One Of Nature S Strongest Molecular Interactions Avitag Historyavitag Was A Patented Biotin Tagging Technology Discovered At Affymax By Drpeter Schatz From A Directed Evolution Approach Calledpeptides On Plasmids The Directed Evolution Approach Identified A Number Of Peptide Sequences That Can Be Biotinylated By The Bira Enzyme Of Ecoliand The Best Of These Sequences Was Called The Avitagecoli Enzyme Bira Biotinylates The 15 Amino Acid Avitag Twice As Fast As Its Natural Substratethe Biotin Carboxyl Carrier Proteinbccpthe Enzymatic Biotinylation Of Proteins Using Avitag Technology Is Preferred Over Chemical Biotinylation Of Proteins Because Bira Enzyme Gentlyand Highly Specificallylabels The Lysine Residue Of The Avitagprior To The Avitagthe Smallest Biotin Accepting Domain Was Comprised Of 75 Amino Acids The Futureas Avidity Maturesthe Company Is Expanding Its Scientific Horizons And Investigating The Use Of Bioluminescence Such As Found In Deep Sea Organisms To Make Its Products Even More Useful To The Scientific Communityavidity Was Approached By Drbruce Bryan Of Prolumeltd In 2004 To Use The Avitag In Conjunction Withavidity Avitaga C Technology Avidity Develops And Sells Molecular Affinity Tools For Connecting Moleculesour Avitaga C Technology Employs A Highly Targeted Enzymatic Conjugation Of A Single Biotin On A Unique 15 Amino Acid Peptide Tag Using The Biotin Ligasebirafrom Ecoliavitaga C Sequence Is Glndifeaqkiewheoriented On Streptavidin Coated Surfacesthis Creates An Ideal Presentation For Molecular Binding Interactionsthe Scientific Benefits Of Avidity S Avitag Technology Have Garnered Noticecurrentlyavitag Technology Is Used By Eight Of The World S Top Ten Pharmaceutical Companies And Is Used By Researchers In Over 30 Countries
