Company Profile

Vast Bioscience Offers The Pharmaceutical Industry A Unique Opportunity To Develop Innovative Drugs With Superior Potencytarget Selectivity And Safetythese Efforts Are Supported By A Management Team With A Strong Pedigree In Biotechnology As Well As Drug Discovery And Developmentusing Out Technology Platform Called Vastversatile Assembly On Stable Templates Enables The Rapid And Simple Synthesis Of An Almost Limitless Array Of Drug Like Molecules With Diversecomplex And Tailored 3D Shapes This Large Array Of 3D Shapes Are Unique And Explore An Enormous Universe Of Unchartered 3D Space When Compared To Pharma Collectionsthis Provides The Ability To Develop Molecules For Lots Of Different Targetsand Indeed The Vast Library Has Provided Hits Over A Number Of Different Target Classesin Additionhistory Has Taught Us That As Molecules Progress From Discovery To Drugs They Have Increased 3D Characterreflecting Improved Safety Being Driven By Improved Selectivitythis 2D To 3D Progression Is Driven By Hit Rates In Early Discoverywith Higher Hit Rates And Promiscuity For 2D Molecules When Compared To 3D Molecules And The Dearth Of Systematically Diverse 3D Shapes In Pharma Collections Of Molecules For Screeningvast Bioscience Addresses The Issue By Providing Large Arrays Of Systematically Diverse 3D Shapes For Screening The Vast Platform Helps Overcome Some Of The Issues Of Hts Such As The Two Dimensional2Dcharacter Of Most Of The Molecules In The Collectionsthese Rod Or Disc Like Shapes Bind To Many Other Sites As Well As The Intended Target Siteresulting In Numerous Side Effectsaddressing This Problem Has Been Difficult Because Of The Complexities Of More 3 Dimensional3Dchemistryparticularly The Number Of Synthetic Steps Required And The Starting Templates Available Vast Is Also Focussed On Developing Products In Pain Managementthe Focus Currently Is On Unlocking The Potential Of Nav1 7 Sodium Channel As A Pain Target